Mac and Cheese Meatloaf Casserole

Mac and cheese meatloaf casserole is my ultimate comfort food combo—savory, juicy meatloaf on the bottom with a creamy, cheesy macaroni layer baked right on top. It’s like two beloved classics baked into one hearty, satisfying dish. Every bite is rich, flavorful, and guaranteed to please a hungry crowd or make weeknight dinner feel like a treat.

Why You’ll Love This Recipe

I love this recipe because it brings together the best of both worlds: a flavorful, tender meatloaf base and a golden, cheesy mac and cheese topping. It’s filling, budget-friendly, and a total crowd-pleaser. Plus, it bakes in one dish, which makes cleanup so much easier. Whether I’m feeding family or meal-prepping for the week, this casserole delivers on flavor and comfort.

Ingredients

(Here’s a tip: Check out the full list of ingredients and measurements in the recipe card below.)

For the meatloaf layer:

• Ground beef

• Breadcrumbs

• Egg

• Onion (finely chopped)

• Garlic (minced)

• Ketchup

• Worcestershire sauce

• Salt

• Black pepper

For the mac and cheese layer:

• Elbow macaroni

• Butter

• All-purpose flour

• Milk

• Cheddar cheese (shredded)

• Salt

• Black pepper

• Paprika (optional for color and flavor)

Directions

1. I preheat the oven to 375°F (190°C) and lightly grease a 9×13-inch baking dish.

2. In a large bowl, I mix the ground beef, breadcrumbs, egg, onion, garlic, ketchup, Worcestershire sauce, salt, and pepper until fully combined.

3. I press the meat mixture evenly into the bottom of the baking dish to form the meatloaf base.

4. I bake the meatloaf layer uncovered for about 20 minutes to let it set slightly before adding the pasta.

5. Meanwhile, I cook the elbow macaroni until just al dente, drain it, and set it aside.

6. In a saucepan, I melt the butter, whisk in the flour to make a roux, then gradually whisk in the milk. I let it simmer until thickened.

7. I stir in shredded cheddar until melted and smooth, then season with salt, pepper, and a little paprika.

8. I mix the cooked macaroni into the cheese sauce, then spoon it evenly over the partially baked meatloaf.

9. I return the dish to the oven and bake for another 20–25 minutes, or until the top is golden and bubbly.

10. I let it rest for a few minutes before slicing and serving.

Servings and timing

This recipe makes about 6–8 servings. It takes roughly 20 minutes to prep and 40–45 minutes to bake, so the total time is around 1 hour and 5 minutes.

Variations

Sometimes I swap ground beef with ground turkey  for a different flavor. I also like to stir in cooked sautéed veggies like bell peppers or mushrooms into the meat layer for extra depth. For the mac and cheese, I mix in other cheeses like mozzarella or pepper jack to spice things up. When I want a crispy topping, I sprinkle breadcrumbs or more cheese on top before baking.

Storage/Reheating

I store leftovers in an airtight container in the fridge for up to 4 days. To reheat, I cover a portion with foil and bake at 350°F (175°C) for 15–20 minutes, or microwave it for 1–2 minutes until heated through. This casserole also freezes well—just cool it completely, wrap tightly, and freeze for up to 2 months. I thaw it overnight in the fridge before reheating.

FAQs

Can I make this casserole ahead of time?

Yes, I often assemble the whole dish, cover it tightly, and refrigerate it for up to 24 hours before baking. I just add a few extra minutes to the baking time if it’s cold from the fridge.

Can I use boxed mac and cheese?

If I’m short on time, I’ve definitely used boxed mac and cheese for the topping. It’s not quite as creamy as homemade, but it still tastes great and saves time.

How do I prevent the meatloaf from being dry?

I make sure not to overbake it, and I always use enough moisture from ketchup, egg, and onion in the meat mix. Letting it rest after baking helps keep it juicy, too.

Can I add vegetables to the casserole?

Absolutely. I sometimes add finely chopped spinach, carrots, or mushrooms to the meatloaf mixture, or stir peas or broccoli into the mac and cheese layer.

What’s the best cheese for the mac and cheese topping?

Sharp cheddar is my go-to, but I also love adding Monterey Jack, gouda, or a bit of cream cheese for extra richness. A blend always gives it great flavor.

Conclusion

Mac and cheese meatloaf casserole is one of those hearty, comforting dishes that makes me excited for dinner every time. It’s the perfect fusion of cheesy, creamy pasta and savory meatloaf, all baked into one warm, satisfying dish. Whether I’m feeding a hungry family or prepping for leftovers, this casserole delivers big-time comfort in every bite.

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